Bugs Henderson was born in Palm Springs, Calif., in 1944 and grew up in Tyler, Texas. At age 6 he picked up his first guitar, and in the early 1960s he began working in a record store in Tyler. Beginning his own band, the Sensors, at age 16 he soon joined his friend, Ronnie Weiss, in a band called Mouse and the Traps. Mouse and the Traps charted its first song, "Public Execution" in 1966. This is where he earned his name "Bugs" overshadowing his real name, Buddy.
Henderson has played with icons such as B.B. King, Eric Clapton, Ted Nugent, James Barton, the Allman Brothers, Leon Russell, Stevie Ray Vaughn, and his good friend Freddie King. One of Bugs' guitars hangs in the Hard Rock Cafe in Dallas.